Digital Health
5 Early-Stage Digital Health Startups Improving Chronic Disease Care
DealBio tracks early-stage digital health startups across Europe and North America. These 5 are using software, connected data and virtual care to support people with long-term conditions between traditional appointments.
- Chronic Care
- Virtual Care
- Digital Therapeutics
- Patient Monitoring
- Sleep Health
- Diabetes
Chronic disease care is increasingly shaped by what happens between visits. Blood pressure, glucose, sleep, pain, fatigue and daily activity can change continuously, while conventional care still depends heavily on periodic appointments and patient recall.
That gap creates room for digital products that make ongoing care more observable and actionable. The strongest products do more than collect data: they translate it into treatment, monitoring or triage workflows that patients and clinicians can use repeatedly.
The five startups below span insomnia, hypertension, inflammatory arthritis, diabetes and sleep apnoea. Their shared thesis is that chronic care can move from episodic snapshots toward continuous support without requiring every interaction to happen in a clinic.inflammatory arthritischronic care
At a Glance
- Di & CareFrance2023Prescription digital insomnia treatment
- HealthNestUnited Kingdom2024Home blood-pressure management
- Mana MedicalUnited Kingdom2023Wearable-guided inflammatory arthritis care
- Bioinspired IntelligenceSpain2025Glucose forecasting and insulin decision support
- Theta SleepUnited Kingdom2024Remote sleep-apnoea pathway
Building Noxxea, a digital medicine for chronic insomnia.
- Country
France- Founded
- 2023
- Sector
- Digital health
- Funding stage
- Seed or earlier
Why Di & Care stands out
Di & Care has moved Noxxea into prescription use rather than positioning it as general sleep coaching. More than 1,000 patients were prescribed the four-week treatment in 2026, and both founders are pharmacists with formal sleep-medicine training.
What Di & Care is building
Noxxea delivers digital cognitive behavioral therapy for insomnia through a smartphone app. The program combines structured daily activities, interactive sessions, sleep diaries and personalized algorithms, while doctors prescribe the treatment through a dedicated platform and can follow patient progress.
Helping people track and manage blood pressure at home with reminders and reports.
- Country
United Kingdom- Founded
- 2024
- Sector
- Consumer health
- Funding stage
- Seed or earlier
- Founders
Why HealthNest stands out
HealthNest is already live on iOS and Android and was co-designed with more than 100 patients and healthcare professionals. The founders bring direct NHS experience, while Adam Wright was selected for the NHS Clinical Entrepreneur Programme.
What HealthNest is building
HealthNest helps people log blood-pressure readings, review trends, receive medication reminders and generate reports for clinicians. The current app turns repeated home readings into a more structured chronic-care workflow between appointments.
Using wearable data to guide daily activity for people with inflammatory arthritis.
- Country
- United Kingdom
- Founded
- 2023
- Sector
- Digital health
- Funding stage
- Seed or earlier
- Founders
Why Mana Medical stands out
Mana Medical combines a patient-facing product with a clinician dashboard and has moved into an eight-week beta study with recruitment support from the National Rheumatoid Arthritis Society. Zinc Ventures invested at pre-seed stage, and DigitalHealth.London selected the startup for its Launchpad programme.
What Mana Medical is building
Patients connect an existing wearable and complete a short daily symptom check-in. Mana Medical combines those inputs into personalized activity and pacing guidance, while its clinician dashboard calculates a daily Patient Stability Index and ranks enrolled patients by who may need attention.
Developing AI software to forecast glucose and support insulin-dosing decisions.
- Country
Spain- Founded
- 2025
- Sector
- Digital health
- Funding stage
- Seed or earlier
Why Bioinspired Intelligence stands out
Bioinspired Intelligence has taken glUCModel into randomized clinical evaluation for adults with type 1 diabetes using insulin injections. All three founders are named on a published glucose-prediction patent application assigned to Complutense and Extremadura universities.
What Bioinspired Intelligence is building
glUCModel combines personalized glucose forecasts, configurable warnings and insulin-dose recommendations in a mobile app. It can forecast glucose changes up to two hours ahead and is being evaluated alongside continuous glucose monitoring and usual insulin-injection routines.
Running a remote clinical sleep service for sleep apnoea diagnosis and care.
- Country
- United Kingdom
- Founded
- 2024
- Sector
- Healthcare services
- Funding stage
- Seed or earlier
Why Theta Sleep stands out
Theta Sleep has built a remote clinical pathway that can run from assessment through treatment. Ramsay Health Care uses the service for remote sleep studies, and the startup has also launched on HealthKey, giving it both provider and employer-benefit distribution routes.
What Theta Sleep is building
Patients can be triaged digitally, complete a sleep test at home and review results with a clinician without attending a sleep laboratory. Treatment and follow-up can continue through the same service, while healthcare providers can use the full pathway or individual modules.
Deal Sourcing for Investors
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Investment perspective
The investable pattern across this group is not simply digitization. Each startup is trying to own a recurring decision inside a long-term care pathway: whether to adjust behavior, review a patient, anticipate a physiological change, deliver a structured treatment or move a diagnostic pathway into the home.
That makes workflow fit as important as engagement. Products that sit beside existing care can scale only if the data they collect changes what a patient or clinician does next. HealthNest and Mana Medical turn repeated home data into more structured follow-up; Bioinspired Intelligence pushes toward predictive decision support; Di & Care productizes an established behavioral treatment; Theta Sleep relocates a clinical pathway rather than merely adding another monitoring layer.
For investors, the clearest milestones are therefore evidence of repeated use, clinical integration and distribution. Chronic-care software becomes more defensible when it is tied to a prescription, reimbursement route, provider workflow or measurable clinical decision rather than relying on engagement alone.
Methodology
DealBio selected these startups from its coverage of early-stage health and longevity startups, focusing on businesses where digital products support the ongoing management, treatment or monitoring of long-term conditions. The selection spans patient self-management, clinician monitoring, predictive decision support, prescribed digital treatment and remote clinical care.
DealBio builds its Startup Briefs using publicly available startup materials, ecosystem sources, market references and professional profiles.