Mapping tissue samples in three dimensions for biological research
Histology examines thin tissue slices, giving a two-dimensional view of a three-dimensional structure. This can miss relevant tissue features and affect treatment decisions. Three-dimensional imaging faces technical barriers in throughput, reliability and scalability.
Clepio Biotech provides 3D tissue imaging and quantitative analysis for research. Researchers send samples for clearing, staining and light-sheet imaging, then receive data on features such as biomarker distribution, cells or blood vessels.
What stands out about Clepio Biotech
Clepio coordinates 3DPATH with over €1,392,000 in net EU contribution allocated under its EIC Transition grant.
The 3DPATH team generated 3D image data with its TRL5 IGEA-3DS prototype, documented in a March 2026 public deliverable.
Works with ACMIT and the University of Bern in 3DPATH on scanner industrialization and clinical research preparation.
The University of Florence lists Clepio as a spin-off originating in its Physics and Astronomy department, incorporated in 2024.
Co-founder and CSO Ludovico Silvestri is a University of Florence associate professor with light-sheet microscopy experience.
The founding project won Start Cup Toscana 2023, a university research business-plan competition, receiving a EUR 5,000 prize.
The founding project received a Pont-Tech incubation-services prize alongside its Start Cup Toscana 2023 win.
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