Purifying extracellular vesicles from biological fluids for research
Extracellular vesicles carry proteins, lipids and genetic material between cells and are potential disease biomarkers. Separating them from biological fluids often takes multiple steps, specialist equipment and skilled operators, with losses in yield, purity and sample integrity.
Acytronix offers a portable device and purification services to isolate extracellular vesicles for research. Its cartridges use antibodies to capture selected vesicle subgroups, then an electrical current releases them for downstream analysis.
What stands out about Acytronix
Acytronix reports its purification system is installed and operational at the Weizmann Institute of Science for researcher use.
Acytronix reports purifying three research groups' raw samples at Weizmann, followed by nanoparticle tracking analysis.
Developed an EV purification and characterization workflow with Wyatt Technology, combining PMED with light-scattering instruments.
Launched an Innovation Check research project with Dr. Mara Saenz de Juano Ribes and ETH Zurich's Animal Physiology Group.
Venture Kick identifies Acytronix as an ETH spin-off based in Schlieren, developing a portable EV purification device.
Won Venture Kick Stage 1 in June 2024, securing CHF 10,000.
Co-founder Adva Krivitsky holds a PhD in nanomedicine, polymer therapeutics and RNA delivery from Tel Aviv University.
Co-founder Vadim Krivitsky received the SKINTEGRITY.CH Young Investigator Award 2023.
Adva Krivitsky received a BRIDGE Proof of Concept fellowship at ETH Zurich to develop the EV separation technology behind Acytronix.
Researchers at Eawag use Acytronix's device to isolate environmental extracellular vesicles from aquatic samples.
A 2025 PMED study isolated bacterial vesicles from culture media and E. coli-spiked human urine, with greater selectivity than ultracentrifugation.
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